![]() Magnetic resonance imaging tracking of stem cells in vivo using iron oxide nanoparticles as a tool for the advancement of clinical regenerative medicine. ![]() Mahmoudi M, Hosseinkhani H, Hosseinkhani M, Boutry S, Simchi A, Journeay WS, et al. MR imaging of tumor associated macrophages with clinically-applicable iron oxide nanoparticles. Theranostics 2011 1:83–101.ĭaldrup-Link HE, Golovko D, Ruffel B, Denardo D, Castaneda R, Ansari C, et al. TCL-SPION-enhanced MRI for the detection of lymph node metastasis in murine experimental model. Lim SW, Kim HW, Jun HY, Park SH, Yoon KH, Kim HS, et al. Detection of amyloid plaques targeted by USPIO-Aβ1-42 in Alzheimer’s disease transgenic mice using magnetic resonance microimaging. Yang J, Wadghiri YZ, Hoang DM, Tsui W, Sun Y, Chung E, et al. Functionalization of inorganic nanoparticles for bioimaging applications. Theranostics 2012 2:3–44.Įrathodiyil N, Ying JY. Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, et al. Superparamagnetic agents in magnetic resonance imaging: physicochemical characteristics and clinical applications. Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. This review summarizes the intrinsic physicochemical properties and pharmacokinetics of magnetic nanoparticles and highlights recent reports describing theranostic systems, including magnetic nanoparticle-based nanoplatforms, and their applications in MRI-guided drug delivery. Such valuable characteristics apply to image-guided drug delivery, especially MRI-guided drug delivery-a form of individualized therapy in which imaging methods are used to guide and monitor delivery of therapeutic agents to target tissues. In addition, surface modifications are easily introduced through conjugation with targeting moieties (e.g., antibodies, peptides, or aptamers), genes, or therapeutic drugs to provide multimodal functionalities. Magnetic iron oxide nanoparticles have been shown to be suitable for use as theranostic agents owing to their intrinsic diagnostic capabilities in magnetic resonance imaging (MRI) applications, hyperthermia properties, and ability to deliver drugs via magnetic attraction and/or systemic delivery.
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